Enum: BiologicalOrganizationEnum

URI: http://example.org/aopwiki-emod/BiologicalOrganizationEnum

Permissible Values

Value	Meaning	Description
Molecular	None	The level of molecules and molecular interactions: receptors, enzymes, protei...
Cellular	None	The level of the cell, or of cells of one type
Tissue	None	The level of the tissue, an organised assembly of cells and extracellular mat...
Organ	None	The level of the whole organ or organ system, such as the liver, kidney, hear...
Individual	None	The level of the whole organism
Population	None	The level of a group of organisms, considered as a group rather than as indiv...

Identifier and Mapping Information

Schema Source

• from schema: http://example.org/aopwiki-emod

LinkML Source

name: BiologicalOrganizationEnum
from_schema: http://example.org/aopwiki-emod
rank: 1000
permissible_values:
  Molecular:
    text: Molecular
    description: 'The level of molecules and molecular interactions: receptors, enzymes,
      proteins, genes and transcripts, and the binding, phosphorylation, and other
      reactions between them. A Key Event at this level occurs in the state, amount,
      or activity of a molecule, described without regard to the cell it occurs in.
      Examples: "Binding of antagonist, PPAR alpha"; "Increase, Nuclear receptor E75b
      gene expression". Molecular Initiating Events sit at this level.'
  Cellular:
    text: Cellular
    description: 'The level of the cell, or of cells of one type. A Key Event at this
      level occurs in the state or behaviour of cells, such as proliferation, differentiation,
      apoptosis or other cell death, or an intracellular process such as mitochondrial
      function, ion flux, or synaptic transmission. The cell is the unit whose state
      changes; the molecular events inside it are its mechanism, not the Key Event.
      Examples: "Increase, Cell injury/death"; "Reduction, 17beta-estradiol synthesis
      by ovarian granulosa cells".'
  Tissue:
    text: Tissue
    description: 'The level of the tissue, an organised assembly of cells and extracellular
      matrix. A Key Event at this level occurs in a tissue''s structure, composition,
      or function, such as hyperplasia, inflammation, fibrosis, a histopathological
      lesion, or the amount of a substance a tissue produces. Examples: "Hyperplasia";
      "Neuroinflammation".'
  Organ:
    text: Organ
    description: 'The level of the whole organ or organ system, such as the liver,
      kidney, heart, lung, brain, or reproductive tract. A Key Event at this level
      occurs in an organ''s structure or function: a malformation, a loss of function,
      or an organ-level physiological output such as heart rate, cochlear function,
      or neuronal network activity. Examples: "Loss, Cochlear function"; "Malformation,
      Male reproductive tract".'
  Individual:
    text: Individual
    description: 'The level of the whole organism. A Key Event at this level occurs
      in the state of an individual: survival, growth, body weight, behaviour, fertility
      or reproduction, or a clinical sign, symptom, or disease in a subject or patient.
      Endpoints at this level are typically the apical endpoints of regulatory toxicity
      tests, and most Adverse Outcomes sit here. Examples: "Increase, Mortality";
      "Parkinsonian motor deficits".'
  Population:
    text: Population
    description: 'The level of a group of organisms, considered as a group rather
      than as individuals. A Key Event at this level occurs in a property of the population:
      growth rate, abundance, recruitment, sex ratio, the incidence or prevalence
      of an outcome, or, in eusocial species, the state of a colony. Used mainly for
      wildlife and pollinator pathways, where, as the handbook says of Adverse Outcomes
      in wildlife, the outcome of concern "will most often be an outcome of demographic
      significance, e.g., population sustainability". Examples: "Decrease, Population
      growth rate"; "Death/Failure, Colony".'