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Outcomes Data Model

A LinkML data model for representing biological measurements, assays, and experimental protocols in the context of outcomes research.

URI: https://w3id.org/EHS-Data-Standards/outcomes-model

Name: outcomes-model

Classes

Class Description
NamedEntity Base class for all named entities in the model
        Assay The specific method or assay used to measure an endpoint
        BarrierIntegrity Epithelial barrier integrity measurements
        CellCultureConditions Detailed cell culture parameters
        CytotoxicityMetrics Cell viability and cytotoxicity measurements
        DetectionMethod Method used for detecting or measuring analytes
        EnvironmentalCondition Environmental parameters during measurement
        EvaporationControl Method used to prevent evaporation during measurement
        FluorescentLabel Fluorescent labeling or tracer used in measurement
        GeneExpressionAnalysis Gene expression measurement methodology
        ImagingProtocol Details about imaging parameters and protocols
        InflammatoryCellProfile Profile of inflammatory cell types and counts
        InputSample Description of the biological sample or experimental manipulation used as inp...
        Measurement A generic class representing the process of measuring a biological endpoint
                ASLHeightMeasurement Measurement of airway surface liquid height
                BALFSputumMeasurement Measurement of bronchoalveolar lavage fluid or sputum components
                CFTRFunctionMeasurement Measurement of CFTR-mediated ion transport function
                CiliaBeatFrequencyMeasurement Measurement of ciliary beat frequency
                EGFRSignalingMeasurement Measurement of EGFR pathway activation and signaling
                GobletCellMeasurement Measurement of goblet cell number or mucin production
                LungFunctionMeasurement Measurement of lung function parameters
                MucociliaryClearanceMeasurement Measurement of mucociliary clearance/transport
                OxidativeStressMeasurement Measurement of oxidative stress markers
                TranscriptionFactorExpressionMeasurement Measurement of transcription factor expression
        MicrobiomeAnalysis Microbiome composition analysis
        Publication Any published piece of information, following Biolink model
        ROSProbe Reactive oxygen species probe and detection details
        SampleCollection Details about biological sample collection
        StainingProtocol Histological or immunofluorescence staining protocol
QuantityValue A quantity value expresses a measurement with a numeric value and a unit

Slots

Slot Description
active_area_percentage Percentage of active ciliated area
alpha_diversity Alpha diversity metric
analysis_method Method for analysis (qRT-PCR, RNA-seq)
antibodies_used Antibodies used in staining
antioxidant_capacity Antioxidant capacity (GSH/GSSG ratio, enzyme activity)
antioxidant_enzyme_activities Antioxidant enzyme activities (SOD, catalase, GPx)
apoptosis_markers Apoptosis marker levels
asl_height_um Airway surface liquid height in micrometers
assay_type Type of assay or method, constrained to OBI assay terms
authors Connects publications to contributor lists, formatted as comma-delimited name...
bacterial_biofilm_details Details about bacterial biofilm preparation and characteristics
bacterial_load Bacterial load (CFU or similar)
barrier_integrity Epithelial barrier integrity measurements
beat_frequency_hz Ciliary beat frequency in Hz
beta_diversity Beta diversity metric
biofilm_clearance_rate Rate of bacterial biofilm clearance
bronchodilator_response Response to bronchodilator
cell_culture_conditions Conditions for cell culture (ALI days, medium, etc
cell_culture_details Detailed cell culture conditions
cell_free_dna Cell-free DNA measurement
cell_type_ratios Ratios between different cell types
cftr_specific_current CFTR-mediated chloride secretory current
cilia_length Length of cilia
cilia_per_cell Number of cilia per cell
ciliary_motion_patterns Patterns of ciliary motion
co2_percentage CO2 percentage in incubator
collection_method Method for sample collection
concentration Concentration of reagent or compound
control_method Method used for control
culture_medium Cell culture medium formulation
cytokine_levels Cytokine and chemokine levels
cytotoxicity_metrics Cytotoxicity measurements
days_at_ali Days at air-liquid interface
decline_rate Longitudinal decline rate
description A detailed description
detection_method_details Detection method details
detection_type Type of detection method
detection_wavelength Wavelength for detection
directionality Directionality of mucociliary transport
dlco Diffusing capacity of the lung for carbon monoxide
dna_damage_markers DNA damage markers (8-OHdG)
dna_extraction_method Method for DNA extraction
donor_count Number of unique donors
dose_response_data Dose-response relationship data
downstream_kinase_activation Activation levels of downstream kinases (ERK, AKT)
egfr_phosphorylation EGFR phosphorylation levels
environmental_conditions Environmental conditions during measurement
eosinophil_percentage Percentage of eosinophils
evaporation_prevention Method used to prevent evaporation
exposure_conditions Exposure or treatment conditions
fef25_75 Forced expiratory flow 25-75%
feno Fractional exhaled nitric oxide
fev1 Forced expiratory volume in 1 second
fev1_fvc_ratio Ratio of FEV1 to FVC
fixation_method Method for tissue/cell fixation
fluorescent_labeling Fluorescent label or tracer used
fluorescent_tracers Fluorescent tracers used for tracking
fluorophore_type Type of fluorophore used
frame_rate Image acquisition frame rate
fvc Forced vital capacity
gene_expression_analysis Gene expression analysis methodology
goblet_cell_count Number or percentage of goblet cells
goblet_to_ciliated_ratio Ratio of goblet cells to ciliated cells
has_maximum_numeric_value The maximum value in a range
has_minimum_numeric_value The minimum value in a range
has_numeric_value The numeric value of a quantity
has_unit The unit of measurement for the quantity
humidity Humidity level
id A unique identifier
imaging_conditions Imaging parameters and conditions
imaging_duration Duration of imaging session
imaging_intervals Time intervals between image acquisitions
imaging_modality Imaging modality used (confocal, OCT, etc
imaging_protocol Imaging protocol and parameters
incubation_conditions Incubation time and temperature
inflammatory_cell_profile Inflammatory cell type profile
inhibitor_sensitive_current Inhibitor-sensitive current measurement
input_sample Description of input samples and manipulations
instrumentation Specific instruments or equipment used
ion_composition Ionic composition (Cl⁻, Na⁺, K⁺)
keywords Keywords or tags for the publication
ldh_release Lactate dehydrogenase release
ligand_expression_levels Expression levels of EGFR ligands
lipid_peroxidation Lipid peroxidation markers (MDA, 8-isoprostane, etc
loading_conditions Conditions for loading probe or dye
lymphocyte_percentage Percentage of lymphocytes
macrophage_percentage Percentage of macrophages
manipulation Experimental manipulation applied
material_used Material used in protocol
measurement_timepoint Timepoint of measurement
mesh_terms Medical Subject Headings (MeSH) terms for indexing
method_assay The method or assay used
microbiome_analysis Microbiome composition analysis
mrna_level mRNA expression level
mtt_reduction MTT reduction assay result
mucin_expression_level Level of mucin gene or protein expression
mucin_protein_concentration Concentration of mucin protein
mucus_layer_thickness Thickness of mucus layer
neutrophil_percentage Percentage of neutrophils
normalization_genes Genes used for normalization
pages Page numbers (start and end) or total pages
particle_tracking_method Method used for tracking particles or mucus
passage_number Cell passage number
pathway_biomarkers Pathway-specific biomarker signatures
pathway_enrichment_scores Enrichment scores for biological pathways
percentage_ciliated_cells Percentage of cells that are ciliated
percentage_positive_cells Percentage of positive cells
periciliary_layer_depth Depth of periciliary layer in micrometers
permeability_coefficient Permeability coefficient
primers_used PCR primers used
probe_positioning Probe or sensor positioning protocol
probe_type Type of probe used
processing_time Time from collection to processing
protein_concentration Total protein concentration
protein_level Protein expression level
protein_oxidation_markers Protein oxidation markers (carbonyls, nitrotyrosine)
protocol_notes Protocol or SOP notes
publication_type Ontology term for categorizing publication format (e
replicates_per_donor Number of replicates per donor
ros_level Reactive oxygen species level
ros_probe ROS probe details
sample_collection_details Sample collection protocol details
sample_type Type of biological sample
sample_volume Volume of sample collected
sensitivity Sensitivity of detection method
sequencing_depth Sequencing depth or read count
sequencing_platform Platform used for sequencing
sequencing_primers Primers used for sequencing (16S, ITS)
sop_reference Reference to standard operating procedure
spatial_resolution Spatial resolution of imaging
staining_method Histological staining method used
staining_protocol Staining protocol details
staining_type Type of staining (histological, immunofluorescence)
storage_conditions Storage temperature and conditions
substrate_type Type of culture substrate
summary Executive summary or abstract of the publication
taxonomic_abundance Taxonomic abundance data
technical_replicates Number of technical replicates
teer_value Transepithelial electrical resistance value
temperature Temperature setting
total_cell_count Total cell count
transport_rate Mucociliary transport rate
viability_percentage Cell viability percentage
viral_infection_details Details about viral infection protocol
viral_spread_rate Rate of viral spread
wavelength Wavelength for excitation or emission
xref Cross-references to supporting databases or webpages

Enumerations

Enumeration Description
AssayTypeEnum Types of assays from the Ontology for Biomedical Investigations (OBI)

Types

Type Description
Boolean A binary (true or false) value
Curie a compact URI
Date a date (year, month and day) in an idealized calendar
DateOrDatetime Either a date or a datetime
Datetime The combination of a date and time
Decimal A real number with arbitrary precision that conforms to the xsd:decimal speci...
Double A real number that conforms to the xsd:double specification
Float A real number that conforms to the xsd:float specification
Integer An integer
Jsonpath A string encoding a JSON Path
Jsonpointer A string encoding a JSON Pointer
Ncname Prefix part of CURIE
Nodeidentifier A URI, CURIE or BNODE that represents a node in a model
Objectidentifier A URI or CURIE that represents an object in the model
Sparqlpath A string encoding a SPARQL Property Path
String A character string
Time A time object represents a (local) time of day, independent of any particular...
Uri a complete URI
Uriorcurie a URI or a CURIE

Subsets

Subset Description