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Class: EGFRSignalingMeasurement

Measurement of EGFR pathway activation and signaling

URI: outcomes_model:EGFRSignalingMeasurement

classDiagram class EGFRSignalingMeasurement click EGFRSignalingMeasurement href "../EGFRSignalingMeasurement/" Measurement <|-- EGFRSignalingMeasurement click Measurement href "../Measurement/" EGFRSignalingMeasurement : description EGFRSignalingMeasurement : downstream_kinase_activation EGFRSignalingMeasurement : egfr_phosphorylation EGFRSignalingMeasurement --> "0..1" QuantityValue : egfr_phosphorylation click QuantityValue href "../QuantityValue/" EGFRSignalingMeasurement : id EGFRSignalingMeasurement : input_sample EGFRSignalingMeasurement --> "0..1" InputSample : input_sample click InputSample href "../InputSample/" EGFRSignalingMeasurement : ligand_expression_levels EGFRSignalingMeasurement : method_assay EGFRSignalingMeasurement --> "0..1" Assay : method_assay click Assay href "../Assay/" EGFRSignalingMeasurement : pathway_biomarkers EGFRSignalingMeasurement : protocol_notes

Inheritance

Slots

Name Cardinality and Range Description Inheritance
egfr_phosphorylation 0..1
QuantityValue		 EGFR phosphorylation levels direct
downstream_kinase_activation 0..1
String		 Activation levels of downstream kinases (ERK, AKT) direct
ligand_expression_levels *
String		 Expression levels of EGFR ligands direct
pathway_biomarkers *
String		 Pathway-specific biomarker signatures direct
input_sample 0..1
InputSample		 Description of input samples and manipulations Measurement
method_assay 0..1
Assay		 The method or assay used Measurement
protocol_notes 0..1
String		 Protocol or SOP notes Measurement
id 1
Uriorcurie		 A unique identifier NamedEntity
description 0..1
String		 A detailed description NamedEntity

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/EHS-Data-Standards/outcomes-model

Mappings

Mapping Type Mapped Value
self outcomes_model:EGFRSignalingMeasurement
native outcomes_model:EGFRSignalingMeasurement

LinkML Source

Direct

name: EGFRSignalingMeasurement
description: Measurement of EGFR pathway activation and signaling
from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
is_a: Measurement
slots:
- egfr_phosphorylation
- downstream_kinase_activation
- ligand_expression_levels
- pathway_biomarkers

Induced

name: EGFRSignalingMeasurement
description: Measurement of EGFR pathway activation and signaling
from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
is_a: Measurement
attributes:
  egfr_phosphorylation:
    name: egfr_phosphorylation
    description: EGFR phosphorylation levels
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: egfr_phosphorylation
    owner: EGFRSignalingMeasurement
    domain_of:
    - EGFRSignalingMeasurement
    range: QuantityValue
    inlined: true
  downstream_kinase_activation:
    name: downstream_kinase_activation
    description: Activation levels of downstream kinases (ERK, AKT)
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: downstream_kinase_activation
    owner: EGFRSignalingMeasurement
    domain_of:
    - EGFRSignalingMeasurement
    range: string
  ligand_expression_levels:
    name: ligand_expression_levels
    description: Expression levels of EGFR ligands
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: ligand_expression_levels
    owner: EGFRSignalingMeasurement
    domain_of:
    - EGFRSignalingMeasurement
    range: string
    multivalued: true
  pathway_biomarkers:
    name: pathway_biomarkers
    description: Pathway-specific biomarker signatures
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: pathway_biomarkers
    owner: EGFRSignalingMeasurement
    domain_of:
    - EGFRSignalingMeasurement
    range: string
    multivalued: true
  input_sample:
    name: input_sample
    description: Description of input samples and manipulations
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: input_sample
    owner: EGFRSignalingMeasurement
    domain_of:
    - Measurement
    range: InputSample
  method_assay:
    name: method_assay
    description: The method or assay used
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: method_assay
    owner: EGFRSignalingMeasurement
    domain_of:
    - Measurement
    range: Assay
  protocol_notes:
    name: protocol_notes
    description: Protocol or SOP notes
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: protocol_notes
    owner: EGFRSignalingMeasurement
    domain_of:
    - Measurement
    range: string
  id:
    name: id
    description: A unique identifier
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    identifier: true
    alias: id
    owner: EGFRSignalingMeasurement
    domain_of:
    - NamedEntity
    range: uriorcurie
    required: true
  description:
    name: description
    description: A detailed description
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: description
    owner: EGFRSignalingMeasurement
    domain_of:
    - NamedEntity
    range: string