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Class: MucinProductionMeasurement

Measurement of mucin production and secretion

URI: outcomes_model:MucinProductionMeasurement

classDiagram class MucinProductionMeasurement click MucinProductionMeasurement href "../MucinProductionMeasurement/" Measurement <|-- MucinProductionMeasurement click Measurement href "../Measurement/" MucinProductionMeasurement : description MucinProductionMeasurement : id MucinProductionMeasurement : input_sample MucinProductionMeasurement --> "0..1" InputSample : input_sample click InputSample href "../InputSample/" MucinProductionMeasurement : method_assay MucinProductionMeasurement --> "0..1" Assay : method_assay click Assay href "../Assay/" MucinProductionMeasurement : mucin_expression_level MucinProductionMeasurement --> "0..1" QuantityValue : mucin_expression_level click QuantityValue href "../QuantityValue/" MucinProductionMeasurement : mucin_protein_concentration MucinProductionMeasurement --> "0..1" QuantityValue : mucin_protein_concentration click QuantityValue href "../QuantityValue/" MucinProductionMeasurement : protocol_notes MucinProductionMeasurement : staining_protocol MucinProductionMeasurement --> "0..1" StainingProtocol : staining_protocol click StainingProtocol href "../StainingProtocol/"

Inheritance

Slots

Name Cardinality and Range Description Inheritance
mucin_expression_level 0..1
QuantityValue		 Level of mucin gene or protein expression (e direct
mucin_protein_concentration 0..1
QuantityValue		 Concentration of mucin protein (both direct quantification and comparative me... direct
staining_protocol 0..1
StainingProtocol		 Staining protocol details direct
input_sample 0..1
InputSample		 Description of input samples and manipulations Measurement
method_assay 0..1
Assay		 The method or assay used Measurement
protocol_notes 0..1
String		 Protocol or SOP notes Measurement
id 1
Uriorcurie		 A unique identifier NamedEntity
description 0..1
String		 A detailed description NamedEntity

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/EHS-Data-Standards/outcomes-model

Mappings

Mapping Type Mapped Value
self outcomes_model:MucinProductionMeasurement
native outcomes_model:MucinProductionMeasurement

LinkML Source

Direct

name: MucinProductionMeasurement
description: Measurement of mucin production and secretion
from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
is_a: Measurement
slots:
- mucin_expression_level
- mucin_protein_concentration
- staining_protocol

Induced

name: MucinProductionMeasurement
description: Measurement of mucin production and secretion
from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
is_a: Measurement
attributes:
  mucin_expression_level:
    name: mucin_expression_level
    description: Level of mucin gene or protein expression (e.g., MUC5AC to MUC5B
      ratio)
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    related_mappings:
    - GO:0070254
    broad_mappings:
    - PATO:0000070
    rank: 1000
    alias: mucin_expression_level
    owner: MucinProductionMeasurement
    domain_of:
    - GobletCellMeasurement
    - MucinProductionMeasurement
    range: QuantityValue
    inlined: true
  mucin_protein_concentration:
    name: mucin_protein_concentration
    description: Concentration of mucin protein (both direct quantification and comparative
      measures, e.g., percent solids from apical secretion)
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    broad_mappings:
    - PATO:0000033
    rank: 1000
    alias: mucin_protein_concentration
    owner: MucinProductionMeasurement
    domain_of:
    - GobletCellMeasurement
    - MucinProductionMeasurement
    range: QuantityValue
    inlined: true
  staining_protocol:
    name: staining_protocol
    description: Staining protocol details
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    exact_mappings:
    - OBI:0000272
    rank: 1000
    alias: staining_protocol
    owner: MucinProductionMeasurement
    domain_of:
    - GeneExpressionMeasurement
    - GobletCellMeasurement
    - MucinProductionMeasurement
    range: StainingProtocol
    inlined: true
  input_sample:
    name: input_sample
    description: Description of input samples and manipulations
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    exact_mappings:
    - OBI:0100051
    related_mappings:
    - OBI:0000747
    rank: 1000
    alias: input_sample
    owner: MucinProductionMeasurement
    domain_of:
    - Measurement
    range: InputSample
  method_assay:
    name: method_assay
    description: The method or assay used
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    exact_mappings:
    - OBI:0000070
    rank: 1000
    alias: method_assay
    owner: MucinProductionMeasurement
    domain_of:
    - Measurement
    range: Assay
  protocol_notes:
    name: protocol_notes
    description: Protocol or SOP notes
    comments:
    - For EGFR signaling include cell type, receptor location in ALI culture, probe
      method, timing
    - For goblet cells include media type, species, disease state, donor age, exposure
      conditions
    - For mucin production include focus on secreted mucins not tethered to goblet
      cells
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    related_mappings:
    - IAO:0000310
    broad_mappings:
    - OBI:0000272
    rank: 1000
    alias: protocol_notes
    owner: MucinProductionMeasurement
    domain_of:
    - Measurement
    range: string
  id:
    name: id
    description: A unique identifier
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    identifier: true
    alias: id
    owner: MucinProductionMeasurement
    domain_of:
    - NamedEntity
    range: uriorcurie
    required: true
  description:
    name: description
    description: A detailed description
    from_schema: https://w3id.org/EHS-Data-Standards/outcomes-model
    rank: 1000
    alias: description
    owner: MucinProductionMeasurement
    domain_of:
    - NamedEntity
    range: string