Class: AdverseOutcomePathway

A sequence of causally linked events at different levels of biological organization that lead from a molecular initiating event through intermediate key events to an adverse health outcome. AOPs provide a structured framework for organizing mechanistic evidence.

URI: soma:AdverseOutcomePathway

 classDiagram
    class AdverseOutcomePathway
    click AdverseOutcomePathway href "../AdverseOutcomePathway/"
      NamedThing <|-- AdverseOutcomePathway
        click NamedThing href "../NamedThing/"

      AdverseOutcomePathway : adverse_outcome





        AdverseOutcomePathway --> "0..1" AdverseOutcome : adverse_outcome
        click AdverseOutcome href "../AdverseOutcome/"



      AdverseOutcomePathway : aopwiki_id

      AdverseOutcomePathway : description

      AdverseOutcomePathway : id

      AdverseOutcomePathway : key_event_relationships





        AdverseOutcomePathway --> "*" KeyEventRelationship : key_event_relationships
        click KeyEventRelationship href "../KeyEventRelationship/"



      AdverseOutcomePathway : key_events





        AdverseOutcomePathway --> "*" KeyEvent : key_events
        click KeyEvent href "../KeyEvent/"



      AdverseOutcomePathway : molecular_initiating_event





        AdverseOutcomePathway --> "0..1" MolecularInitiatingEvent : molecular_initiating_event
        click MolecularInitiatingEvent href "../MolecularInitiatingEvent/"



      AdverseOutcomePathway : name

      AdverseOutcomePathway : stressors

Inheritance

NamedThing
- AdverseOutcomePathway

Slots

Name	Cardinality and Range	Description	Inheritance
aopwiki_id	0..1 String	The AOP-Wiki identifier for this entity (e	direct
molecular_initiating_event	0..1 MolecularInitiatingEvent	The molecular initiating event that starts this AOP	direct
key_events	* KeyEvent	The key events in this AOP (intermediate events between MIE and AO)	direct
key_event_relationships	* KeyEventRelationship	The key event relationships connecting events in this AOP	direct
adverse_outcome	0..1 AdverseOutcome	The adverse outcome that is the apical endpoint of this AOP	direct
stressors	* String	Chemical or physical stressors that can trigger this AOP	direct
id	1 Uriorcurie	A unique identifier for the entity	NamedThing
name	0..1 String	A human-readable name for the entity	NamedThing
description	0..1 String	A detailed description of the entity	NamedThing

Usages

used by	used in	type	used
Container	adverse_outcome_pathways	range	AdverseOutcomePathway

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/EHS-Data-Standards/soma

Mappings

Mapping Type	Mapped Value
self	soma:AdverseOutcomePathway
native	soma:AdverseOutcomePathway

LinkML Source

Direct

name: AdverseOutcomePathway
description: A sequence of causally linked events at different levels of biological
  organization that lead from a molecular initiating event through intermediate key
  events to an adverse health outcome. AOPs provide a structured framework for organizing
  mechanistic evidence.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: NamedThing
slots:
- aopwiki_id
- molecular_initiating_event
- key_events
- key_event_relationships
- adverse_outcome
- stressors

Induced

name: AdverseOutcomePathway
description: A sequence of causally linked events at different levels of biological
  organization that lead from a molecular initiating event through intermediate key
  events to an adverse health outcome. AOPs provide a structured framework for organizing
  mechanistic evidence.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: NamedThing
attributes:
  aopwiki_id:
    name: aopwiki_id
    description: The AOP-Wiki identifier for this entity (e.g., "AOP:411" for an AOP,
      "KE:1234" for a key event).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: aopwiki_id
    owner: AdverseOutcomePathway
    domain_of:
    - KeyEvent
    - AdverseOutcome
    - AdverseOutcomePathway
    range: string
  molecular_initiating_event:
    name: molecular_initiating_event
    description: The molecular initiating event that starts this AOP.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: molecular_initiating_event
    owner: AdverseOutcomePathway
    domain_of:
    - AdverseOutcomePathway
    range: MolecularInitiatingEvent
    inlined: true
  key_events:
    name: key_events
    description: The key events in this AOP (intermediate events between MIE and AO).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: key_events
    owner: AdverseOutcomePathway
    domain_of:
    - Container
    - AdverseOutcomePathway
    range: KeyEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  key_event_relationships:
    name: key_event_relationships
    description: The key event relationships connecting events in this AOP.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: key_event_relationships
    owner: AdverseOutcomePathway
    domain_of:
    - AdverseOutcomePathway
    range: KeyEventRelationship
    multivalued: true
    inlined: true
    inlined_as_list: true
  adverse_outcome:
    name: adverse_outcome
    description: The adverse outcome that is the apical endpoint of this AOP.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: adverse_outcome
    owner: AdverseOutcomePathway
    domain_of:
    - AdverseOutcomePathway
    range: AdverseOutcome
    inlined: true
  stressors:
    name: stressors
    description: Chemical or physical stressors that can trigger this AOP.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: stressors
    owner: AdverseOutcomePathway
    domain_of:
    - AdverseOutcomePathway
    range: string
    multivalued: true
  id:
    name: id
    description: A unique identifier for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    identifier: true
    alias: id
    owner: AdverseOutcomePathway
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: AdverseOutcomePathway
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: string
  description:
    name: description
    description: A detailed description of the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: AdverseOutcomePathway
    domain_of:
    - NamedThing
    range: string