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Class: KeyEvent

A measurable change in biological state that is a step in an Adverse Outcome Pathway. Key Events represent the biological perturbations that assays measure to provide evidence for AOP-based mechanistic understanding. Key events can be Molecular Initiating Events (MIEs), intermediate Key Events, or Adverse Outcomes at the organism/population level.

URI: ECTO:1000000

 classDiagram
    class KeyEvent
    click KeyEvent href "../KeyEvent/"
      NamedThing <|-- KeyEvent
        click NamedThing href "../NamedThing/"


      KeyEvent <|-- MolecularInitiatingEvent
        click MolecularInitiatingEvent href "../MolecularInitiatingEvent/"


      KeyEvent : aopwiki_id

      KeyEvent : biological_action





        KeyEvent --> "0..1" BiologicalActionEnum : biological_action
        click BiologicalActionEnum href "../BiologicalActionEnum/"



      KeyEvent : biological_object

      KeyEvent : biological_process

      KeyEvent : description

      KeyEvent : downstream_key_events





        KeyEvent --> "*" KeyEvent : downstream_key_events
        click KeyEvent href "../KeyEvent/"



      KeyEvent : id

      KeyEvent : level_of_biological_organization





        KeyEvent --> "0..1" BiologicalOrganizationLevelEnum : level_of_biological_organization
        click BiologicalOrganizationLevelEnum href "../BiologicalOrganizationLevelEnum/"



      KeyEvent : name

      KeyEvent : occurs_in_anatomy

      KeyEvent : occurs_in_cell_type

      KeyEvent : upstream_key_events





        KeyEvent --> "*" KeyEvent : upstream_key_events
        click KeyEvent href "../KeyEvent/"

Inheritance

Slots

Name Cardinality and Range Description Inheritance
biological_process 0..1
Uriorcurie		 The biological process affected by this key event direct
biological_object 0..1
String		 The biological entity affected (protein, cell, tissue, organ) direct
biological_action 0..1
BiologicalActionEnum		 The type of change (increased, decreased, altered, impaired) direct
level_of_biological_organization 0..1
BiologicalOrganizationLevelEnum		 The level of biological organization at which this key event occurs direct
occurs_in_cell_type 0..1
Uriorcurie		 The cell type in which this key event occurs direct
occurs_in_anatomy 0..1
Uriorcurie		 The anatomical location where this key event occurs direct
aopwiki_id 0..1
String		 The AOP-Wiki identifier for this entity (e direct
upstream_key_events *
KeyEvent		 Key events that lead to this key event (upstream in the pathway) direct
downstream_key_events *
KeyEvent		 Key events that follow this key event (downstream in the pathway) direct
id 1
Uriorcurie		 A unique identifier for the entity NamedThing
name 0..1
String		 A human-readable name for the entity NamedThing
description 0..1
String		 A detailed description of the entity NamedThing

Usages

used by used in type used
Container key_events range KeyEvent
KeyEvent upstream_key_events range KeyEvent
KeyEvent downstream_key_events range KeyEvent
KeyEventRelationship upstream_event range KeyEvent
KeyEventRelationship downstream_event range KeyEvent
AdverseOutcomePathway key_events range KeyEvent
MolecularInitiatingEvent upstream_key_events range KeyEvent
MolecularInitiatingEvent downstream_key_events range KeyEvent
Assay informs_on_key_event range KeyEvent
CiliaryFunctionAssay informs_on_key_event range KeyEvent
ASLAssay informs_on_key_event range KeyEvent
MucociliaryClearanceAssay informs_on_key_event range KeyEvent
OxidativeStressAssay informs_on_key_event range KeyEvent
CFTRFunctionAssay informs_on_key_event range KeyEvent
EGFRSignalingAssay informs_on_key_event range KeyEvent
GobletCellAssay informs_on_key_event range KeyEvent
BALFSputumAssay informs_on_key_event range KeyEvent
LungFunctionAssay informs_on_key_event range KeyEvent
FoxJExpressionAssay informs_on_key_event range KeyEvent
GeneExpressionAssay informs_on_key_event range KeyEvent

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/EHS-Data-Standards/soma

Mappings

Mapping Type Mapped Value
self ECTO:1000000
native soma:KeyEvent

LinkML Source

Direct

name: KeyEvent
description: A measurable change in biological state that is a step in an Adverse
  Outcome Pathway. Key Events represent the biological perturbations that assays measure
  to provide evidence for AOP-based mechanistic understanding. Key events can be Molecular
  Initiating Events (MIEs), intermediate Key Events, or Adverse Outcomes at the organism/population
  level.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: NamedThing
slots:
- biological_process
- biological_object
- biological_action
- level_of_biological_organization
- occurs_in_cell_type
- occurs_in_anatomy
- aopwiki_id
- upstream_key_events
- downstream_key_events
class_uri: ECTO:1000000

Induced

name: KeyEvent
description: A measurable change in biological state that is a step in an Adverse
  Outcome Pathway. Key Events represent the biological perturbations that assays measure
  to provide evidence for AOP-based mechanistic understanding. Key events can be Molecular
  Initiating Events (MIEs), intermediate Key Events, or Adverse Outcomes at the organism/population
  level.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: NamedThing
attributes:
  biological_process:
    name: biological_process
    description: The biological process affected by this key event. Should reference
      a GO biological process term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_process
    owner: KeyEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    range: uriorcurie
    pattern: ^GO:\d{7}$
  biological_object:
    name: biological_object
    description: The biological entity affected (protein, cell, tissue, organ).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_object
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: string
  biological_action:
    name: biological_action
    description: The type of change (increased, decreased, altered, impaired).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_action
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: BiologicalActionEnum
  level_of_biological_organization:
    name: level_of_biological_organization
    description: The level of biological organization at which this key event occurs.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: level_of_biological_organization
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: BiologicalOrganizationLevelEnum
  occurs_in_cell_type:
    name: occurs_in_cell_type
    description: The cell type in which this key event occurs. Should reference a
      Cell Ontology (CL) term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: occurs_in_cell_type
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: uriorcurie
    pattern: ^CL:\d{7}$
  occurs_in_anatomy:
    name: occurs_in_anatomy
    description: The anatomical location where this key event occurs. Should reference
      a UBERON anatomy term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: occurs_in_anatomy
    owner: KeyEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    range: uriorcurie
    pattern: ^UBERON:\d{7}$
  aopwiki_id:
    name: aopwiki_id
    description: The AOP-Wiki identifier for this entity (e.g., "AOP:411" for an AOP,
      "KE:1234" for a key event).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: aopwiki_id
    owner: KeyEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    - AdverseOutcomePathway
    range: string
  upstream_key_events:
    name: upstream_key_events
    description: Key events that lead to this key event (upstream in the pathway).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: upstream_key_events
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: KeyEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  downstream_key_events:
    name: downstream_key_events
    description: Key events that follow this key event (downstream in the pathway).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: downstream_key_events
    owner: KeyEvent
    domain_of:
    - KeyEvent
    range: KeyEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  id:
    name: id
    description: A unique identifier for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    identifier: true
    alias: id
    owner: KeyEvent
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: KeyEvent
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: string
  description:
    name: description
    description: A detailed description of the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: KeyEvent
    domain_of:
    - NamedThing
    range: string
class_uri: ECTO:1000000