Class: MolecularInitiatingEvent

name: MolecularInitiatingEvent
description: The initial molecular-level perturbation that starts an Adverse Outcome
  Pathway. The MIE is the direct interaction between a stressor and a biological target
  (e.g., receptor binding, enzyme inhibition).
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: KeyEvent
slots:
- target_molecule

name: MolecularInitiatingEvent
description: The initial molecular-level perturbation that starts an Adverse Outcome
  Pathway. The MIE is the direct interaction between a stressor and a biological target
  (e.g., receptor binding, enzyme inhibition).
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: KeyEvent
attributes:
  target_molecule:
    name: target_molecule
    description: The molecular target of the stressor in the MIE (e.g., receptor,
      enzyme).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: target_molecule
    owner: MolecularInitiatingEvent
    domain_of:
    - MolecularInitiatingEvent
    range: string
  biological_process:
    name: biological_process
    description: The biological process affected by this key event. Should reference
      a GO biological process term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_process
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    range: uriorcurie
    pattern: ^GO:\d{7}$
  biological_object:
    name: biological_object
    description: The biological entity affected (protein, cell, tissue, organ).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_object
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: string
  biological_action:
    name: biological_action
    description: The type of change (increased, decreased, altered, impaired).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: biological_action
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: BiologicalActionEnum
  level_of_biological_organization:
    name: level_of_biological_organization
    description: The level of biological organization at which this key event occurs.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: level_of_biological_organization
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: BiologicalOrganizationLevelEnum
  occurs_in_cell_type:
    name: occurs_in_cell_type
    description: The cell type in which this key event occurs. Should reference a
      Cell Ontology (CL) term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: occurs_in_cell_type
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: uriorcurie
    pattern: ^CL:\d{7}$
  occurs_in_anatomy:
    name: occurs_in_anatomy
    description: The anatomical location where this key event occurs. Should reference
      a UBERON anatomy term.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: occurs_in_anatomy
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    range: uriorcurie
    pattern: ^UBERON:\d{7}$
  aopwiki_id:
    name: aopwiki_id
    description: The AOP-Wiki identifier for this entity (e.g., "AOP:411" for an AOP,
      "KE:1234" for a key event).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: aopwiki_id
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    - AdverseOutcome
    - AdverseOutcomePathway
    range: string
  upstream_key_events:
    name: upstream_key_events
    description: Key events that lead to this key event (upstream in the pathway).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: upstream_key_events
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: KeyEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  downstream_key_events:
    name: downstream_key_events
    description: Key events that follow this key event (downstream in the pathway).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: downstream_key_events
    owner: MolecularInitiatingEvent
    domain_of:
    - KeyEvent
    range: KeyEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  id:
    name: id
    description: A unique identifier for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    identifier: true
    alias: id
    owner: MolecularInitiatingEvent
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: MolecularInitiatingEvent
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: string
  description:
    name: description
    description: A detailed description of the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: MolecularInitiatingEvent
    domain_of:
    - NamedThing
    range: string