Class: Aop

An AOP describes a sequence of events commencing with initial interaction(s) of a stressor with a biomolecule within an organism that causes a perturbation in its biology (i.e., molecular initiating event, MIE), which can progress through a dependent series of intermediate key events (KEs) and culminate in an adverse outcome (AO) considered relevant to risk assessment or regulatory decision-making. AOPs are composed of a causal sequence of upstream to downstream KEs, representing a cascading series of measurable biological changes that can be expected to occur if the perturbation is sufficiently severe (i.e., in terms of potency, duration, frequency) to drive the pathway all the way to the AO. Importantly, AOPs do not describe every detail of the biology but instead focus on describing critical steps or check-points along the path to adversity, which are both measurable and have potential predictive value for regulatory application.

URI: http://example.org/aopwiki-emod/Aop

classDiagram class Aop click Aop href "../Aop/" Aop : abstract Aop : applicability_of_the_aop Aop : assays Aop --> "*" Assay : assays click Assay href "../Assay/" Aop : assigned_license_id Aop --> "0..1" AssignedLicense : assigned_license_id click AssignedLicense href "../AssignedLicense/" Aop : authors Aop : background Aop : changed_at Aop : completion_score Aop : corresponding_author_id Aop --> "0..1" User : corresponding_author_id click User href "../User/" Aop : created_at Aop : development_strategy Aop : events Aop --> "*" AopToEvent : events click AopToEvent href "../AopToEvent/" Aop : graphical_representation_image_uid Aop : handbook_id Aop --> "0..1" Handbook : handbook_id click Handbook href "../Handbook/" Aop : has_references Aop : has_structured_methods Aop : id Aop : ke_relationships Aop --> "*" AopToKeRelationship : ke_relationships click AopToKeRelationship href "../AopToKeRelationship/" Aop : key_event_essentiality Aop : known_modulating_factors Aop : legacy Aop : life_stages Aop --> "*" AopToLifeStage : life_stages click AopToLifeStage href "../AopToLifeStage/" Aop : mean_event_score Aop : mean_ker_score Aop : oecd_project Aop : oecd_status_id Aop --> "0..1" OecdStatus : oecd_status_id click OecdStatus href "../OecdStatus/" Aop : optional_considerations Aop : overall_assessment Aop : overall_assessment_file_uid Aop : project_129 Aop : prototypical_stressors Aop --> "*" AopToPrototypicalStressor : prototypical_stressors click AopToPrototypicalStressor href "../AopToPrototypicalStressor/" Aop : quantitative_considerations Aop : sexes Aop --> "*" AopToSex : sexes click AopToSex href "../AopToSex/" Aop : short_name Aop : taxons Aop --> "*" AopToTaxon : taxons click AopToTaxon href "../AopToTaxon/" Aop : title Aop : updated_at Aop : weight_of_evidence_summary

Slots

Name	Cardinality and Range	Description	Inheritance
created_at	0..1 Datetime	Timestamp of when the record was created	direct
updated_at	0..1 Datetime	Timestamp of when the record was last updated	direct
id	1 Integer		direct
title	0..1 String		direct
short_name	0..1 String		direct
corresponding_author_id	0..1 User		direct
abstract	0..1 String		direct
authors	0..1 String		direct
applicability_of_the_aop	0..1 String		direct
key_event_essentiality	0..1 String		direct
weight_of_evidence_summary	0..1 String		direct
quantitative_considerations	0..1 String		direct
optional_considerations	0..1 String		direct
overall_assessment	0..1 String		direct
background	0..1 String		direct
oecd_project	0..1 String		direct
oecd_status_id	0..1 OecdStatus		direct
graphical_representation_image_uid	0..1 String		direct
legacy	0..1 Boolean		direct
overall_assessment_file_uid	0..1 String		direct
changed_at	0..1 String		direct
development_strategy	0..1 String		direct
known_modulating_factors	0..1 String		direct
assigned_license_id	0..1 AssignedLicense		direct
handbook_id	0..1 Handbook		direct
completion_score	0..1 Float		direct
mean_ker_score	0..1 Float		direct
mean_event_score	0..1 Float		direct
has_references	0..1 Boolean		direct
project_129	0..1 Boolean		direct
has_structured_methods	0..1 Boolean		direct
assays	* Assay		direct
prototypical_stressors	* AopToPrototypicalStressor		direct
events	* AopToEvent		direct
ke_relationships	* AopToKeRelationship		direct
life_stages	* AopToLifeStage		direct
sexes	* AopToSex		direct
taxons	* AopToTaxon		direct

Usages

used by	used in	type	used
Assay	aops	range	Aop
AopToEvent	aop_id	range	Aop
AopToLifeStage	aop_id	range	Aop
AopToKeRelationship	aop_id	range	Aop
AopToSex	aop_id	range	Aop
AopToPrototypicalStressor	aop_id	range	Aop
AopToTaxon	aop_id	range	Aop
HarmonizedAop	new_aop_id	range	Aop
HarmonizedAop	source_aop_id	range	Aop

Identifier and Mapping Information

Schema Source

from schema: http://example.org/aopwiki-emod

Mappings

Mapping Type	Mapped Value
self	http://example.org/aopwiki-emod/Aop
native	http://example.org/aopwiki-emod/Aop

LinkML Source

Direct

name: Aop
description: An AOP describes a sequence of events commencing with initial interaction(s)
  of a stressor with a biomolecule within an organism that causes a perturbation in
  its biology (i.e., molecular initiating event, MIE), which can progress through
  a dependent series of intermediate key events (KEs) and culminate in an adverse
  outcome (AO) considered relevant to risk assessment or regulatory decision-making.
  AOPs are composed of a causal sequence of upstream to downstream KEs, representing
  a cascading series of measurable biological changes that can be expected to occur
  if the perturbation is sufficiently severe (i.e., in terms of potency, duration,
  frequency) to drive the pathway all the way to the AO. Importantly, AOPs do not
  describe every detail of the biology but instead focus on describing critical steps
  or check-points along the path to adversity, which are both measurable and have
  potential predictive value for regulatory application.
from_schema: http://example.org/aopwiki-emod
slots:
- created_at
- updated_at
attributes:
  id:
    name: id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    identifier: true
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Assay
    - Observation
    - Evidence
    - Stressor
    - Citation
    - BiologicalAction
    - BiologicalObject
    - BiologicalProcess
    - LevelOfBiologicalOrganization
    - AopToEvent
    - AopToLifeStage
    - AopToKeRelationship
    - AopToSex
    - AopToPrototypicalStressor
    - AopToTaxon
    - AssignedLicense
    - BioTargetFamily
    - CellTerm
    - ConfidenceLevel
    - Directness
    - EventToLifeStage
    - EventToSex
    - EventToTaxon
    - ExperimentSetup
    - ExperimentType
    - Handbook
    - HarmonizedAop
    - HarmonizedEvent
    - License
    - LifeStageTerm
    - OecdStatus
    - OrganTerm
    - KeRelationshipToLifeStage
    - KeRelationshipToSex
    - KeRelationshipToTaxon
    - SexTerm
    - EventComponent
    - TaxonTerm
    - TestGuideline
    - User
    range: integer
    required: true
  title:
    name: title
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - Assay
    - Citation
  short_name:
    name: short_name
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
  corresponding_author_id:
    name: corresponding_author_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: User
    inlined: true
  abstract:
    name: abstract
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  authors:
    name: authors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Citation
  applicability_of_the_aop:
    name: applicability_of_the_aop
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  key_event_essentiality:
    name: key_event_essentiality
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  weight_of_evidence_summary:
    name: weight_of_evidence_summary
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  quantitative_considerations:
    name: quantitative_considerations
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  optional_considerations:
    name: optional_considerations
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  overall_assessment:
    name: overall_assessment
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  background:
    name: background
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  oecd_project:
    name: oecd_project
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  oecd_status_id:
    name: oecd_status_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: OecdStatus
    inlined: true
  graphical_representation_image_uid:
    name: graphical_representation_image_uid
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  legacy:
    name: legacy
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: boolean
  overall_assessment_file_uid:
    name: overall_assessment_file_uid
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  changed_at:
    name: changed_at
    from_schema: http://example.org/aopwiki-emod
    domain_of:
    - Aop
  development_strategy:
    name: development_strategy
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  known_modulating_factors:
    name: known_modulating_factors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
  assigned_license_id:
    name: assigned_license_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: AssignedLicense
    inlined: true
  handbook_id:
    name: handbook_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: Handbook
    inlined: true
  completion_score:
    name: completion_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: float
  mean_ker_score:
    name: mean_ker_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: float
  mean_event_score:
    name: mean_event_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: float
  has_references:
    name: has_references
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: boolean
  project_129:
    name: project_129
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: boolean
  has_structured_methods:
    name: has_structured_methods
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: boolean
  assays:
    name: assays
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Citation
    - BioTargetFamily
    - TestGuideline
    range: Assay
    multivalued: true
  prototypical_stressors:
    name: prototypical_stressors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    range: AopToPrototypicalStressor
    multivalued: true
    inlined: true
    inlined_as_list: true
  events:
    name: events
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Assay
    - Observation
    - BioTargetFamily
    - TestGuideline
    range: AopToEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  ke_relationships:
    name: ke_relationships
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Assay
    range: AopToKeRelationship
    multivalued: true
    inlined: true
    inlined_as_list: true
  life_stages:
    name: life_stages
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToLifeStage
    multivalued: true
    inlined: true
    inlined_as_list: true
  sexes:
    name: sexes
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToSex
    multivalued: true
    inlined: true
    inlined_as_list: true
  taxons:
    name: taxons
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToTaxon
    multivalued: true
    inlined: true
    inlined_as_list: true

Induced

name: Aop
description: An AOP describes a sequence of events commencing with initial interaction(s)
  of a stressor with a biomolecule within an organism that causes a perturbation in
  its biology (i.e., molecular initiating event, MIE), which can progress through
  a dependent series of intermediate key events (KEs) and culminate in an adverse
  outcome (AO) considered relevant to risk assessment or regulatory decision-making.
  AOPs are composed of a causal sequence of upstream to downstream KEs, representing
  a cascading series of measurable biological changes that can be expected to occur
  if the perturbation is sufficiently severe (i.e., in terms of potency, duration,
  frequency) to drive the pathway all the way to the AO. Importantly, AOPs do not
  describe every detail of the biology but instead focus on describing critical steps
  or check-points along the path to adversity, which are both measurable and have
  potential predictive value for regulatory application.
from_schema: http://example.org/aopwiki-emod
attributes:
  id:
    name: id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    identifier: true
    alias: id
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Assay
    - Observation
    - Evidence
    - Stressor
    - Citation
    - BiologicalAction
    - BiologicalObject
    - BiologicalProcess
    - LevelOfBiologicalOrganization
    - AopToEvent
    - AopToLifeStage
    - AopToKeRelationship
    - AopToSex
    - AopToPrototypicalStressor
    - AopToTaxon
    - AssignedLicense
    - BioTargetFamily
    - CellTerm
    - ConfidenceLevel
    - Directness
    - EventToLifeStage
    - EventToSex
    - EventToTaxon
    - ExperimentSetup
    - ExperimentType
    - Handbook
    - HarmonizedAop
    - HarmonizedEvent
    - License
    - LifeStageTerm
    - OecdStatus
    - OrganTerm
    - KeRelationshipToLifeStage
    - KeRelationshipToSex
    - KeRelationshipToTaxon
    - SexTerm
    - EventComponent
    - TaxonTerm
    - TestGuideline
    - User
    range: integer
  title:
    name: title
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: title
    owner: Aop
    domain_of:
    - Aop
    - Event
    - Assay
    - Citation
    range: string
  short_name:
    name: short_name
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: short_name
    owner: Aop
    domain_of:
    - Aop
    - Event
    range: string
  corresponding_author_id:
    name: corresponding_author_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: corresponding_author_id
    owner: Aop
    domain_of:
    - Aop
    range: User
    inlined: true
  abstract:
    name: abstract
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: abstract
    owner: Aop
    domain_of:
    - Aop
    range: string
  authors:
    name: authors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: authors
    owner: Aop
    domain_of:
    - Aop
    - Citation
    range: string
  applicability_of_the_aop:
    name: applicability_of_the_aop
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: applicability_of_the_aop
    owner: Aop
    domain_of:
    - Aop
    range: string
  key_event_essentiality:
    name: key_event_essentiality
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: key_event_essentiality
    owner: Aop
    domain_of:
    - Aop
    range: string
  weight_of_evidence_summary:
    name: weight_of_evidence_summary
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: weight_of_evidence_summary
    owner: Aop
    domain_of:
    - Aop
    range: string
  quantitative_considerations:
    name: quantitative_considerations
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: quantitative_considerations
    owner: Aop
    domain_of:
    - Aop
    range: string
  optional_considerations:
    name: optional_considerations
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: optional_considerations
    owner: Aop
    domain_of:
    - Aop
    range: string
  overall_assessment:
    name: overall_assessment
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: overall_assessment
    owner: Aop
    domain_of:
    - Aop
    range: string
  background:
    name: background
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: background
    owner: Aop
    domain_of:
    - Aop
    range: string
  oecd_project:
    name: oecd_project
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: oecd_project
    owner: Aop
    domain_of:
    - Aop
    range: string
  oecd_status_id:
    name: oecd_status_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: oecd_status_id
    owner: Aop
    domain_of:
    - Aop
    range: OecdStatus
    inlined: true
  graphical_representation_image_uid:
    name: graphical_representation_image_uid
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: graphical_representation_image_uid
    owner: Aop
    domain_of:
    - Aop
    range: string
  legacy:
    name: legacy
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: legacy
    owner: Aop
    domain_of:
    - Aop
    range: boolean
  overall_assessment_file_uid:
    name: overall_assessment_file_uid
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: overall_assessment_file_uid
    owner: Aop
    domain_of:
    - Aop
    range: string
  changed_at:
    name: changed_at
    from_schema: http://example.org/aopwiki-emod
    alias: changed_at
    owner: Aop
    domain_of:
    - Aop
    range: string
  development_strategy:
    name: development_strategy
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: development_strategy
    owner: Aop
    domain_of:
    - Aop
    range: string
  known_modulating_factors:
    name: known_modulating_factors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: known_modulating_factors
    owner: Aop
    domain_of:
    - Aop
    range: string
  assigned_license_id:
    name: assigned_license_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: assigned_license_id
    owner: Aop
    domain_of:
    - Aop
    range: AssignedLicense
    inlined: true
  handbook_id:
    name: handbook_id
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: handbook_id
    owner: Aop
    domain_of:
    - Aop
    range: Handbook
    inlined: true
  completion_score:
    name: completion_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: completion_score
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: float
  mean_ker_score:
    name: mean_ker_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: mean_ker_score
    owner: Aop
    domain_of:
    - Aop
    range: float
  mean_event_score:
    name: mean_event_score
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: mean_event_score
    owner: Aop
    domain_of:
    - Aop
    range: float
  has_references:
    name: has_references
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: has_references
    owner: Aop
    domain_of:
    - Aop
    range: boolean
  project_129:
    name: project_129
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: project_129
    owner: Aop
    domain_of:
    - Aop
    range: boolean
  has_structured_methods:
    name: has_structured_methods
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: has_structured_methods
    owner: Aop
    domain_of:
    - Aop
    range: boolean
  assays:
    name: assays
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: assays
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Citation
    - BioTargetFamily
    - TestGuideline
    range: Assay
    multivalued: true
  prototypical_stressors:
    name: prototypical_stressors
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: prototypical_stressors
    owner: Aop
    domain_of:
    - Aop
    range: AopToPrototypicalStressor
    multivalued: true
    inlined: true
    inlined_as_list: true
  events:
    name: events
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: events
    owner: Aop
    domain_of:
    - Aop
    - Assay
    - Observation
    - BioTargetFamily
    - TestGuideline
    range: AopToEvent
    multivalued: true
    inlined: true
    inlined_as_list: true
  ke_relationships:
    name: ke_relationships
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: ke_relationships
    owner: Aop
    domain_of:
    - Aop
    - Assay
    range: AopToKeRelationship
    multivalued: true
    inlined: true
    inlined_as_list: true
  life_stages:
    name: life_stages
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: life_stages
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToLifeStage
    multivalued: true
    inlined: true
    inlined_as_list: true
  sexes:
    name: sexes
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: sexes
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToSex
    multivalued: true
    inlined: true
    inlined_as_list: true
  taxons:
    name: taxons
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: taxons
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    range: AopToTaxon
    multivalued: true
    inlined: true
    inlined_as_list: true
  created_at:
    name: created_at
    description: Timestamp of when the record was created
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: created_at
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Assay
    - Observation
    - Evidence
    - Stressor
    - Citation
    - BiologicalAction
    - BiologicalObject
    - BiologicalProcess
    - LevelOfBiologicalOrganization
    - AopToEvent
    - AopToLifeStage
    - AopToKeRelationship
    - AopToSex
    - AopToPrototypicalStressor
    - AopToTaxon
    - AssignedLicense
    - BioTargetFamily
    - CellTerm
    - ConfidenceLevel
    - Directness
    - EventToLifeStage
    - EventToSex
    - EventToTaxon
    - ExperimentSetup
    - ExperimentType
    - Handbook
    - HarmonizedAop
    - HarmonizedEvent
    - License
    - LifeStageTerm
    - OecdStatus
    - OrganTerm
    - KeRelationshipToLifeStage
    - KeRelationshipToSex
    - KeRelationshipToTaxon
    - SexTerm
    - EventComponent
    - TaxonTerm
    - TestGuideline
    range: datetime
  updated_at:
    name: updated_at
    description: Timestamp of when the record was last updated
    from_schema: http://example.org/aopwiki-emod
    rank: 1000
    alias: updated_at
    owner: Aop
    domain_of:
    - Aop
    - Event
    - KeRelationship
    - Assay
    - Observation
    - Evidence
    - Stressor
    - Citation
    - BiologicalAction
    - BiologicalObject
    - BiologicalProcess
    - LevelOfBiologicalOrganization
    - AopToEvent
    - AopToLifeStage
    - AopToKeRelationship
    - AopToSex
    - AopToPrototypicalStressor
    - AopToTaxon
    - AssignedLicense
    - BioTargetFamily
    - CellTerm
    - ConfidenceLevel
    - Directness
    - EventToLifeStage
    - EventToSex
    - EventToTaxon
    - ExperimentSetup
    - ExperimentType
    - Handbook
    - HarmonizedAop
    - HarmonizedEvent
    - License
    - LifeStageTerm
    - OecdStatus
    - OrganTerm
    - KeRelationshipToLifeStage
    - KeRelationshipToSex
    - KeRelationshipToTaxon
    - SexTerm
    - EventComponent
    - TaxonTerm
    - TestGuideline
    range: datetime