Class: CFTRFunctionOutput
Measurement results from a CFTR function assay. Contains the measured values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology measurements.
classDiagram
class CFTRFunctionOutput
click CFTRFunctionOutput href "../CFTRFunctionOutput/"
AssayOutputMeasurement <|-- CFTRFunctionOutput
click AssayOutputMeasurement href "../AssayOutputMeasurement/"
CFTRFunctionOutput : cftr_chloride_secretion
CFTRFunctionOutput --> "0..1" QuantityValue : cftr_chloride_secretion
click QuantityValue href "../QuantityValue/"
CFTRFunctionOutput : cftr_forskolin_response
CFTRFunctionOutput --> "0..1" QuantityValue : cftr_forskolin_response
click QuantityValue href "../QuantityValue/"
CFTRFunctionOutput : cftr_specific_current
CFTRFunctionOutput --> "0..1" QuantityValue : cftr_specific_current
click QuantityValue href "../QuantityValue/"
CFTRFunctionOutput : data_in_figure_only
CFTRFunctionOutput : description
CFTRFunctionOutput : evidence
CFTRFunctionOutput --> "* _recommended_" EvidenceItem : evidence
click EvidenceItem href "../EvidenceItem/"
CFTRFunctionOutput : experimental_group
CFTRFunctionOutput --> "0..1" ExperimentalGroupEnum : experimental_group
click ExperimentalGroupEnum href "../ExperimentalGroupEnum/"
CFTRFunctionOutput : id
CFTRFunctionOutput : inhibitor_sensitive_current
CFTRFunctionOutput --> "0..1" QuantityValue : inhibitor_sensitive_current
click QuantityValue href "../QuantityValue/"
CFTRFunctionOutput : measured_under
CFTRFunctionOutput --> "0..1" ExposureCondition : measured_under
click ExposureCondition href "../ExposureCondition/"
CFTRFunctionOutput : name
CFTRFunctionOutput : nasal_potential_difference
CFTRFunctionOutput --> "0..1" QuantityValue : nasal_potential_difference
click QuantityValue href "../QuantityValue/"
CFTRFunctionOutput : sweat_chloride_concentration
CFTRFunctionOutput --> "0..1" QuantityValue : sweat_chloride_concentration
click QuantityValue href "../QuantityValue/"
Inheritance
- NamedThing
- AssayOutputMeasurement
- CFTRFunctionOutput
- AssayOutputMeasurement
Slots
| Name | Cardinality and Range | Description | Inheritance |
|---|---|---|---|
| cftr_chloride_secretion | 0..1 QuantityValue |
CFTR-mediated chloride secretion in uA/cm2 | direct |
| cftr_forskolin_response | 0..1 QuantityValue |
Forskolin-stimulated CFTR response | direct |
| inhibitor_sensitive_current | 0..1 QuantityValue |
Inhibitor-sensitive current measurement | direct |
| cftr_specific_current | 0..1 QuantityValue |
CFTR-specific chloride secretory current | direct |
| sweat_chloride_concentration | 0..1 QuantityValue |
Sweat chloride concentration in mEq/L (CF diagnostic) | direct |
| nasal_potential_difference | 0..1 QuantityValue |
Nasal potential difference in mV | direct |
| evidence | * recommended EvidenceItem |
Evidence items backing this object's claims | AssayOutputMeasurement |
| experimental_group | 0..1 ExperimentalGroupEnum |
The role of this output record's group in the experimental design: control, v... | AssayOutputMeasurement |
| measured_under | 0..1 ExposureCondition |
Reference (by id) to the specific ExposureCondition this output record was me... | AssayOutputMeasurement |
| data_in_figure_only | 0..1 Boolean |
True when the quantitative values for this output record are reported only in... | AssayOutputMeasurement |
| id | 1 Uriorcurie |
A unique identifier for the entity | NamedThing |
| name | 0..1 String |
A human-readable name for the entity | NamedThing |
| description | 0..1 String |
A detailed description of the entity | NamedThing |
Usages
| used by | used in | type | used |
|---|---|---|---|
| CFTRFunctionAssay | has_specified_output | range | CFTRFunctionOutput |
Identifier and Mapping Information
Schema Source
- from schema: https://w3id.org/EHS-Data-Standards/soma
Mappings
| Mapping Type | Mapped Value |
|---|---|
| self | soma:CFTRFunctionOutput |
| native | soma:CFTRFunctionOutput |
LinkML Source
Direct
name: CFTRFunctionOutput
description: Measurement results from a CFTR function assay. Contains the measured
values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology
measurements.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: AssayOutputMeasurement
slots:
- cftr_chloride_secretion
- cftr_forskolin_response
- inhibitor_sensitive_current
- cftr_specific_current
- sweat_chloride_concentration
- nasal_potential_difference
Induced
name: CFTRFunctionOutput
description: Measurement results from a CFTR function assay. Contains the measured
values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology
measurements.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: AssayOutputMeasurement
attributes:
cftr_chloride_secretion:
name: cftr_chloride_secretion
description: CFTR-mediated chloride secretion in uA/cm2.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: cftr_chloride_secretion
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
cftr_forskolin_response:
name: cftr_forskolin_response
description: Forskolin-stimulated CFTR response.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: cftr_forskolin_response
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
inhibitor_sensitive_current:
name: inhibitor_sensitive_current
description: Inhibitor-sensitive current measurement.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: inhibitor_sensitive_current
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
cftr_specific_current:
name: cftr_specific_current
description: CFTR-specific chloride secretory current.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: cftr_specific_current
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
sweat_chloride_concentration:
name: sweat_chloride_concentration
description: Sweat chloride concentration in mEq/L (CF diagnostic).
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: sweat_chloride_concentration
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
nasal_potential_difference:
name: nasal_potential_difference
description: Nasal potential difference in mV.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: nasal_potential_difference
owner: CFTRFunctionOutput
domain_of:
- CFTRFunctionOutput
range: QuantityValue
inlined: true
evidence:
name: evidence
description: Evidence items backing this object's claims. Each one carries an
exact quote from a cited publication.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: evidence
owner: CFTRFunctionOutput
domain_of:
- KeyEvent
- KeyEventRelationship
- Assay
- AssayOutputMeasurement
range: EvidenceItem
recommended: true
multivalued: true
inlined: true
inlined_as_list: true
experimental_group:
name: experimental_group
description: 'The role of this output record''s group in the experimental design:
control, vehicle control, baseline, treated, recovery, or sham. Lets extraction
distinguish the control/baseline response from the treated response so a change
relative to control can be assembled downstream.'
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: experimental_group
owner: CFTRFunctionOutput
domain_of:
- AssayOutputMeasurement
range: ExperimentalGroupEnum
measured_under:
name: measured_under
description: Reference (by id) to the specific ExposureCondition this output record
was measured under. Links each set of response values to the concentration/treatment
it corresponds to, so a dose-response series keeps each response paired with
its exposure level. The referenced condition should be listed in the assay's
has_exposure_condition.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: measured_under
owner: CFTRFunctionOutput
domain_of:
- AssayOutputMeasurement
range: ExposureCondition
inlined: false
data_in_figure_only:
name: data_in_figure_only
description: True when the quantitative values for this output record are reported
only in a figure or chart and could not be read from the text. The record then
documents that the endpoint was measured and where its data lives (via an evidence
item's figure_reference and article_section), without numeric values. This keeps
figure-only results visible to reviewers in the workbook instead of silently
dropping them.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
alias: data_in_figure_only
owner: CFTRFunctionOutput
domain_of:
- AssayOutputMeasurement
range: boolean
id:
name: id
description: A unique identifier for the entity.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
identifier: true
alias: id
owner: CFTRFunctionOutput
domain_of:
- NamedThing
- Unit
- NamedEntity
range: uriorcurie
required: true
name:
name: name
description: A human-readable name for the entity.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
slot_uri: schema:name
alias: name
owner: CFTRFunctionOutput
domain_of:
- NamedThing
- Unit
- NamedEntity
range: string
description:
name: description
description: A detailed description of the entity.
from_schema: https://w3id.org/EHS-Data-Standards/soma
rank: 1000
slot_uri: schema:description
alias: description
owner: CFTRFunctionOutput
domain_of:
- NamedThing
range: string