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Class: CFTRFunctionOutput

Measurement results from a CFTR function assay. Contains the measured values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology measurements.

URI: soma:CFTRFunctionOutput

 classDiagram
    class CFTRFunctionOutput
    click CFTRFunctionOutput href "../CFTRFunctionOutput/"
      AssayOutputMeasurement <|-- CFTRFunctionOutput
        click AssayOutputMeasurement href "../AssayOutputMeasurement/"

      CFTRFunctionOutput : cftr_chloride_secretion





        CFTRFunctionOutput --> "0..1" QuantityValue : cftr_chloride_secretion
        click QuantityValue href "../QuantityValue/"



      CFTRFunctionOutput : cftr_forskolin_response





        CFTRFunctionOutput --> "0..1" QuantityValue : cftr_forskolin_response
        click QuantityValue href "../QuantityValue/"



      CFTRFunctionOutput : cftr_specific_current





        CFTRFunctionOutput --> "0..1" QuantityValue : cftr_specific_current
        click QuantityValue href "../QuantityValue/"



      CFTRFunctionOutput : data_in_figure_only

      CFTRFunctionOutput : description

      CFTRFunctionOutput : evidence





        CFTRFunctionOutput --> "* _recommended_" EvidenceItem : evidence
        click EvidenceItem href "../EvidenceItem/"



      CFTRFunctionOutput : experimental_group





        CFTRFunctionOutput --> "0..1" ExperimentalGroupEnum : experimental_group
        click ExperimentalGroupEnum href "../ExperimentalGroupEnum/"



      CFTRFunctionOutput : id

      CFTRFunctionOutput : inhibitor_sensitive_current





        CFTRFunctionOutput --> "0..1" QuantityValue : inhibitor_sensitive_current
        click QuantityValue href "../QuantityValue/"



      CFTRFunctionOutput : measured_under





        CFTRFunctionOutput --> "0..1" ExposureCondition : measured_under
        click ExposureCondition href "../ExposureCondition/"



      CFTRFunctionOutput : name

      CFTRFunctionOutput : nasal_potential_difference





        CFTRFunctionOutput --> "0..1" QuantityValue : nasal_potential_difference
        click QuantityValue href "../QuantityValue/"



      CFTRFunctionOutput : sweat_chloride_concentration





        CFTRFunctionOutput --> "0..1" QuantityValue : sweat_chloride_concentration
        click QuantityValue href "../QuantityValue/"




Inheritance

Slots

Name Cardinality and Range Description Inheritance
cftr_chloride_secretion 0..1
QuantityValue
CFTR-mediated chloride secretion in uA/cm2 direct
cftr_forskolin_response 0..1
QuantityValue
Forskolin-stimulated CFTR response direct
inhibitor_sensitive_current 0..1
QuantityValue
Inhibitor-sensitive current measurement direct
cftr_specific_current 0..1
QuantityValue
CFTR-specific chloride secretory current direct
sweat_chloride_concentration 0..1
QuantityValue
Sweat chloride concentration in mEq/L (CF diagnostic) direct
nasal_potential_difference 0..1
QuantityValue
Nasal potential difference in mV direct
evidence * recommended
EvidenceItem
Evidence items backing this object's claims AssayOutputMeasurement
experimental_group 0..1
ExperimentalGroupEnum
The role of this output record's group in the experimental design: control, v... AssayOutputMeasurement
measured_under 0..1
ExposureCondition
Reference (by id) to the specific ExposureCondition this output record was me... AssayOutputMeasurement
data_in_figure_only 0..1
Boolean
True when the quantitative values for this output record are reported only in... AssayOutputMeasurement
id 1
Uriorcurie
A unique identifier for the entity NamedThing
name 0..1
String
A human-readable name for the entity NamedThing
description 0..1
String
A detailed description of the entity NamedThing

Usages

used by used in type used
CFTRFunctionAssay has_specified_output range CFTRFunctionOutput

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/EHS-Data-Standards/soma

Mappings

Mapping Type Mapped Value
self soma:CFTRFunctionOutput
native soma:CFTRFunctionOutput

LinkML Source

Direct

name: CFTRFunctionOutput
description: Measurement results from a CFTR function assay. Contains the measured
  values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology
  measurements.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: AssayOutputMeasurement
slots:
- cftr_chloride_secretion
- cftr_forskolin_response
- inhibitor_sensitive_current
- cftr_specific_current
- sweat_chloride_concentration
- nasal_potential_difference

Induced

name: CFTRFunctionOutput
description: Measurement results from a CFTR function assay. Contains the measured
  values for CFTR-mediated chloride secretion, forskolin response, and related electrophysiology
  measurements.
from_schema: https://w3id.org/EHS-Data-Standards/soma
is_a: AssayOutputMeasurement
attributes:
  cftr_chloride_secretion:
    name: cftr_chloride_secretion
    description: CFTR-mediated chloride secretion in uA/cm2.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: cftr_chloride_secretion
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  cftr_forskolin_response:
    name: cftr_forskolin_response
    description: Forskolin-stimulated CFTR response.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: cftr_forskolin_response
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  inhibitor_sensitive_current:
    name: inhibitor_sensitive_current
    description: Inhibitor-sensitive current measurement.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: inhibitor_sensitive_current
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  cftr_specific_current:
    name: cftr_specific_current
    description: CFTR-specific chloride secretory current.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: cftr_specific_current
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  sweat_chloride_concentration:
    name: sweat_chloride_concentration
    description: Sweat chloride concentration in mEq/L (CF diagnostic).
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: sweat_chloride_concentration
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  nasal_potential_difference:
    name: nasal_potential_difference
    description: Nasal potential difference in mV.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: nasal_potential_difference
    owner: CFTRFunctionOutput
    domain_of:
    - CFTRFunctionOutput
    range: QuantityValue
    inlined: true
  evidence:
    name: evidence
    description: Evidence items backing this object's claims. Each one carries an
      exact quote from a cited publication.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: evidence
    owner: CFTRFunctionOutput
    domain_of:
    - KeyEvent
    - KeyEventRelationship
    - Assay
    - AssayOutputMeasurement
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  experimental_group:
    name: experimental_group
    description: 'The role of this output record''s group in the experimental design:
      control, vehicle control, baseline, treated, recovery, or sham. Lets extraction
      distinguish the control/baseline response from the treated response so a change
      relative to control can be assembled downstream.'
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: experimental_group
    owner: CFTRFunctionOutput
    domain_of:
    - AssayOutputMeasurement
    range: ExperimentalGroupEnum
  measured_under:
    name: measured_under
    description: Reference (by id) to the specific ExposureCondition this output record
      was measured under. Links each set of response values to the concentration/treatment
      it corresponds to, so a dose-response series keeps each response paired with
      its exposure level. The referenced condition should be listed in the assay's
      has_exposure_condition.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: measured_under
    owner: CFTRFunctionOutput
    domain_of:
    - AssayOutputMeasurement
    range: ExposureCondition
    inlined: false
  data_in_figure_only:
    name: data_in_figure_only
    description: True when the quantitative values for this output record are reported
      only in a figure or chart and could not be read from the text. The record then
      documents that the endpoint was measured and where its data lives (via an evidence
      item's figure_reference and article_section), without numeric values. This keeps
      figure-only results visible to reviewers in the workbook instead of silently
      dropping them.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    alias: data_in_figure_only
    owner: CFTRFunctionOutput
    domain_of:
    - AssayOutputMeasurement
    range: boolean
  id:
    name: id
    description: A unique identifier for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    identifier: true
    alias: id
    owner: CFTRFunctionOutput
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: uriorcurie
    required: true
  name:
    name: name
    description: A human-readable name for the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:name
    alias: name
    owner: CFTRFunctionOutput
    domain_of:
    - NamedThing
    - Unit
    - NamedEntity
    range: string
  description:
    name: description
    description: A detailed description of the entity.
    from_schema: https://w3id.org/EHS-Data-Standards/soma
    rank: 1000
    slot_uri: schema:description
    alias: description
    owner: CFTRFunctionOutput
    domain_of:
    - NamedThing
    range: string